-Iodo-nitrobenzenes in the Rabbit
نویسندگان
چکیده
In a study of the metabolism of the 19 members of the chloromononitrobenzene series (for summary and references see Table 4 of Bray, James & Thorpe, 1957 b) it was observed that in the rabbit several compounds were converted into mercapturic acids by replacement of a relatively labile chlorine atom. The formation of mercapturic acid by acetylcysteyldebromination of4-bromo-3:5-dichloronitrobenzene (Betts, Bray, James & Thorpe, 1957) and of 2-bromo-4-chloro-, 2-bromo-5-chloroand 4-bromo-3-chloro-nitrobenzene (Bray, James & Thorpe, 1957 a) has also been noted. It was therefore of interest to examine the metabolic fate of some other halogenonitrobenzenes with particular reference to the formation of mercapturic acids. For this purpose the monohalogenonitrobenzenes were chosen since they were more readily available than polyhalogenonitrobenzenes. Some preliminary experimnents have been reported by Bray & James (1957). Betts et al. (1957) found that in the rabbit 2:4:5and 2:4:6-trichloronitrobenzene yielded metabolites in which a chlorine atom was replaced by an hydroxyl group. The present investigation has revealed further examples of hydroxyldehalogenation.
منابع مشابه
The metabolism of pentachloronitrobenzene and 2:3:4:6-tetrachloronitrobenzene and the formation of mercapturic acids in the rabbit.
In the rabbit 2:3:5:6-tetrachloronitrobenzene is metabolized by reduction of the nitro group, hydroxylation and mercapturic acid formation (Bray, Hybs, James & Thorpe, 1953). The last reaction is of particular interest since it is accompanied by loss of a nitro group directly attached to the benzene ring. Two further examples of this type of reaction were encountered when pentachloronitrobenzen...
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